Using the Framework in workflow should be considered important. It will not only build your website, but also help to build it faster. It also asks developer to pay attention to some other features like designer overlook, including style-sheet print or make your site more responsive. Lets keep the light on few frameworks:
1) Foundation :
It gives you a great, adjustable grid that could be easily nested. It also focuses on mobile web and let you develop mobile web first.
2) Gumby :
Gumby uses a adjustable, customizable, 960px wide grid used by many web-designers. Gumby is ideal to build. clutter free responsive site.
Now-a-Days Bootstrap is the most popular framework and used by a large number of impressive sites. Bootstrap contains the most features of allowing designers to create anything they want.